Sharing deep generative representation for perceived image reconstruction from human brain activity

Decoding human brain activities via functional magnetic resonance imaging (fMRI) has gained increasing attention in recent years. While encouraging results have been reported in brain states classification tasks, reconstructing the details of human visual experience still remains difficult. Two main challenges that hinder the development of effective models are the perplexing fMRI measurement noise and the high dimensionality of limited data instances. Existing methods generally suffer from one or both of these issues and yield dissatisfactory results. In this paper, we tackle this problem by casting the reconstruction of visual stimulus as the Bayesian inference of missing view in a multiview latent variable model. Sharing a common latent representation, our joint generative model of external stimulus and brain response is not only "deep" in extracting nonlinear features from visual images, but also powerful in capturing correlations among voxel activities of fMRI recordings. The nonlinearity and deep structure endow our model with strong representation ability, while the correlations of voxel activities are critical for suppressing noise and improving prediction. We devise an efficient variational Bayesian method to infer the latent variables and the model parameters. To further improve the reconstruction accuracy, the latent representations of testing instances are enforced to be close to that of their neighbours from the training set via posterior regularization. Experiments on three fMRI recording datasets demonstrate that our approach can more accurately reconstruct visual stimuli

Analytical considerations of flow boiling heat transfer in metal-foam filled tubes

Flow boiling in metal-foam filled tube was analytically investigated based on a modified microstructure model, an original boiling heat transfer model and fin analysis for metal foams. Microstructure model of metal foams was established, by which fiber diameter and surface area density were precisely predicted. The heat transfer model for flow boiling in metal foams was based on annular pattern, in which two phase fluid was composed by vapor region in the center of the tube and liquid region near the wall. However, it was assumed that nucleate boiling performed only in the liquid region. Fin analysis and heat transfer network for metal foams were integrated to obtain the convective heat transfer coefficient at interface. The analytical solution was verified by its good agreement with experimental data. The parametric study on heat transfer coefficient and boiling mechanism was also carried out

A Location-Sentiment-Aware Recommender System for Both Home-Town and Out-of-Town Users

Spatial item recommendation has become an important means to help people discover interesting locations, especially when people pay a visit to unfamiliar regions. Some current researches are focusing on modelling individual and collective geographical preferences for spatial item recommendation based on users' check-in records, but they fail to explore the phenomenon of user interest drift across geographical regions, i.e., users would show different interests when they travel to different regions. Besides, they ignore the influence of public comments for subsequent users' check-in behaviors. Specifically, it is intuitive that users would refuse to check in to a spatial item whose historical reviews seem negative overall, even though it might fit their interests. Therefore, it is necessary to recommend the right item to the right user at the right location. In this paper, we propose a latent probabilistic generative model called LSARS to mimic the decision-making process of users' check-in activities both in home-town and out-of-town scenarios by adapting to user interest drift and crowd sentiments, which can learn location-aware and sentiment-aware individual interests from the contents of spatial items and user reviews. Due to the sparsity of user activities in out-of-town regions, LSARS is further designed to incorporate the public preferences learned from local users' check-in behaviors. Finally, we deploy LSARS into two practical application scenes: spatial item recommendation and target user discovery. Extensive experiments on two large-scale location-based social networks (LBSNs) datasets show that LSARS achieves better performance than existing state-of-the-art methods.Comment: Accepted by KDD 201

Semi-supervised Deep Generative Modelling of Incomplete Multi-Modality Emotional Data

There are threefold challenges in emotion recognition. First, it is difficult to recognize human's emotional states only considering a single modality. Second, it is expensive to manually annotate the emotional data. Third, emotional data often suffers from missing modalities due to unforeseeable sensor malfunction or configuration issues. In this paper, we address all these problems under a novel multi-view deep generative framework. Specifically, we propose to model the statistical relationships of multi-modality emotional data using multiple modality-specific generative networks with a shared latent space. By imposing a Gaussian mixture assumption on the posterior approximation of the shared latent variables, our framework can learn the joint deep representation from multiple modalities and evaluate the importance of each modality simultaneously. To solve the labeled-data-scarcity problem, we extend our multi-view model to semi-supervised learning scenario by casting the semi-supervised classification problem as a specialized missing data imputation task. To address the missing-modality problem, we further extend our semi-supervised multi-view model to deal with incomplete data, where a missing view is treated as a latent variable and integrated out during inference. This way, the proposed overall framework can utilize all available (both labeled and unlabeled, as well as both complete and incomplete) data to improve its generalization ability. The experiments conducted on two real multi-modal emotion datasets demonstrated the superiority of our framework.Comment: arXiv admin note: text overlap with arXiv:1704.07548, 2018 ACM Multimedia Conference (MM'18

Online Bayesian Multiple Kernel Bipartite Ranking

Abstract Bipartite ranking aims to maximize the area under the ROC curve (AUC) of a decision function. To tackle this problem when the data appears sequentially, existing online AUC maximization methods focus on seeking a point estimate of the decision function in a linear or predefined single kernel space, and cannot learn effective kernels automatically from the streaming data. In this paper, we first develop a Bayesian multiple kernel bipartite ranking model, which circumvents the kernel selection problem by estimating a posterior distribution over the model weights. To make our model applicable to streaming data, we then present a kernelized online Bayesian passive-aggressive learning framework by maintaining a variational approximation to the posterior based on data augmentation. Furthermore, to efficiently deal with large-scale data, we design a fixed budget strategy which can effectively control online model complexity. Extensive experimental studies confirm the superiority of our Bayesian multi-kernel approach

Hexaaqua­manganese(II) dipicrate dihydrate

In the title compound, [Mn(H2O)6](C6H2N3O7)2·2H2O, the manganese cation, on an inversion centre, is coordinated by six water mol­ecules, but the picrate anion has no coordinative inter­action with the manganese cation. The anions in the stack are linked via short inter­molecular O⋯C (3.013 and 2.973 Å) and C⋯C (3.089 and 3.065 Å) contacts and hydrogen bonds

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie